Human Sera
Cayman Chemical LevobetaxololhydrochLRIde 50mg
A β1-adrenergic receptor antagonist (Ki = 0.76 nM for the human receptor); selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM); inhibits isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM); topical application reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension at 150 UG/eye
Cayman Chemical PhosphatIdylethnolamInsoy 50mg
A mixture of phosphatidylethanolamines isolated from soy; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules
Sino Biological Recombinant Human IGF1R Protein (ECD, His Tag), Endotoxin-Free
A DNA sequence encoding the extracellular domain (Met1-Asn932) of human IGF1R (NP_000866.1) was expressed with a C-terminal polyhistidine tag.
Cayman Chemical HenIcosnoIc AcId 100mg
A very long-chain saturated fatty acid; found in plants and animals, including human milk fat; also found in LPS from Gram-negative bacteria
Cayman Chemical C4 CeramIded18 14 0 100mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical 3MethylquInoxalIn2carboxy 50mg
A major metabolite of olaquindox; induces cell cycle arrest at the S phase and is toxic to Chang liver cells in a concentration- and time-dependent manner; has been used as a marker of olaquindox use in livestock applications
Cayman Chemical Betamethason 17-valerate 50mg
A glucocorticoid with anti-inflammatory activity; inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively); topical application of a 0.12% ointment blocks increases in EAr weight in a rat model of EAr edema induced by croton oil
Cayman Chemical ElaIdIc AcId 100mg
A trans fatty acid; reduces arachidonic acid-induced HHT and HETE formation and increases arachidonic acid-induced synthesis of PGE2, PGF2α, PGD2, and TXB2 in isolated human platelets; induces apoptosis in HUVECs from 0.1-5 mmol/L; reduces palmitic acid-induced cardiac and hepatic autophagy in mice at 100 mg/kg
Cayman Chemical FenpropathrIn 50mg
A pyrethroid insecticide; a slow activator of Nav1.8; decreases the number of Colorado potato beetle (L. decemlineata) adults and third stage larvae at 0.01%; has been found in watershed sediment samples
Cayman Chemical TermItomycamIde B 50mg
A fatty acid amide from T. titanicus that at 0.1 μg/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin
Cayman Chemical EsmololhydrochlorIde 50mg
A β1-AR antagonist; binds to β1-ARs (Kd = 100 nM in isolated cardiac myocytes); 34-fold selective for β1- over β2-ARs; inhibits ICa.L and the INa in rat cardiac myocytes (IC50s = 50 and 169 μM, respectively)
Cayman Chemical CarbutamIde 100mg
A first generation sulfonylurea; inhibits KATP channels in β-cells (IC50 = 173 µM); reduces blood glucose levels in anesthetized dogs at 50 mg/kg; increases ventricular fibrillation in a rat model of LAD coronary artery ligation-induced cardiac ischemia
Cayman Chemical Apum lptopylum Bgaptn 100mg
A furanocoumarin derivative with diverse biological activities; decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis at 50 μM; has photosensitizing activity; increases the number of sunburn cells in guinea pig skin in response to UVA radiation; increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain at 10 mg/kg; inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in GSH levels in the spinal cord and sciatic nerve in rats; inhibits CYP3A4 (IC50 = ~25 μM) in human liver microsomes
Cayman Chemical 2TrIfluoromethyl2methoxyc 50mg
A potent activator of Nrf2; increases the expression of GCLM and NQO1 in human bronchial epithelial cells at 10 μM; increases GCLM and NQO1 expression by 4.5- and 4.6-fold, respectively, in the small intestine in mice at 50 mg/kg
Cayman Chemical PendImethalIn 50mg
A dinitroaniline herbicide; controls johnsongrass and increases seed cotton yield from 0.56 to 1.12 kg/ha; induces the production of ROS and genotoxicity in isolated human peripheral lymphocytes from 25-500 µM; increases renal and hepatic protein carbonylation, lipid peroxidation, necrosis, leukocyte infiltration, and formation of pyknotic nuclei in rats at 62.5, 125, and 250 mg/kg